In sepsis, a low platelet count is a well-known indicator of poor prognosis.
#Low mpv blood test free
Platelets activated by immunoglobulin, thrombin, collagen, or phorbol myristate acetate (PMA) can also release free mitochondria that behave in a damage-associated molecular pattern that amplifies the inflammatory response. They activate the NLRP3 inflammasome in immune cells, which induces the expression of IL-1. These platelets are morphologically different in shape (spherical with pseudopods) and size (larger), but functionally poorly competent, inducing thrombogenic activity and adverse clinical outcomes. The reason why the platelet, and strictly the mean platelet volume (MPV) marked the biological behavior of sepsis is that the inflammation caused by infectious pathogens induces a systemic response with the production of pro-inflammatory cytokines, thrombopoietin, and other substances that stimulate the massive production of young platelets. It has been shown that coagulation and platelet activation can occur in an early phase of this syndrome, playing a decisive role in its pathophysiology. The hemostatic system is not an exception and is frequently disturbed. It is considered a systemic process with a high probability of organic impact. Sepsis is a dysregulated response of the body to infectious disease, of high prevalence, and in which few measures have not been able to reduce its mortality, except for the early initiation of antibiotic therapy and adequate support for organ failure. The Central University of Ecuador will cover the publication fees in case the manuscript be accepted.Ĭompeting interests: The authors have declared that no competing interests exist. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the manuscript and its Supporting Information files.įunding: The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript.
Received: MaAccepted: DecemPublished: January 6, 2022Ĭopyright: © 2022 Vélez-Páez et al. PLoS ONE 17(1):Įditor: Andrea Ballotta, IRCCS Policlinico S.Donato, ITALY (2022) Mean platelet volume and mean platelet volume to platelet count ratio as predictors of severity and mortality in sepsis. Citation: Vélez-Páez JL, Legua P, Vélez-Páez P, Irigoyen E, Andrade H, Jara A, et al.
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